Basic Hep C Treatment Terms

Basic Hep C Treatment Terms

This page contains a list of basic hepatitis C treatment terms. At the bottom of this list there are links to more information about hepatitis C/hep C/HCV (hepatitis C/hep C/HCV all mean hepatitis C).

The Hepatitis C Virus and its Treatments (The Basic Facts)
The hep C virus (HCV) spreads through blood. It infects cells and then uses those cells to create new copies of itself. Those copies then leave those cells and move on to infect others, creating more and more copies.

The goal of hep C treatment is to stop the virus from making copies of itself to the extent that a person’s HCV viral load, the amount of virus they have in their body, is lowered so much that it cannot be found – is ‘undetectable’ – 6 months after completing treatment. That is called a sustained viral response, or SVR. When SVR is achieved, the virus can no longer be detected in the blood and liver disease from hep C has halted.  Studies have shown that a long-term risk for liver cancer still remains.

For more information, Hepatitis Education Canada has a video about basic hepatitis C information that can be played in multiple languages. The Hepatitis C: The Basics interactive on-line learning module also has more information about hep C.

Hepatitis C Basics on-line course ad
The BC Centre for Disease Control has created Hepatitis C: The Basics. It is a free, go-at-your-own-pace learning module. It covers: how hepatitis C is spread, how to get tested, how best to live with the disease, and how to manage treatment and post treatment.

Also, the documentary film “Deal with it: Untold stories of hepatitis C in Canada” exposes the state of Canada’s Hepatitis C epidemic, one of the most pressing but least discussed health concerns facing the country today, can be watched here for free.

Hep C Treatment Terms

Lasting a long time without going away.

A formulary is a health insurance provider’s official list of pharmaceutical drugs that they have approved for coverage.

Hep C Antibody Test
The hep C antibody test is a blood test that is done to find out if one’s immune system has made antibodies to fight the hep C virus This is the first test done to see if someone has hep C. A person who has been exposed to the hep C virus – whether the virus is still in their bloodstream or not – will always have hep C antibodies. This doesn’t mean that they still have the virus.

Hep C Genotype
A hep C genotype is a strain or type of hep C.  There are 6 main types of the hep C as well as sub-types.  A person get infected with more than one genotype, so prevention and harm reduction are important. Knowing your hep C genotype is important as it affects the type of treatment prescribed, the treatment’s duration, and the treatment’s success

More information can be found in the BC government’s Hepatitis C Genotypes Healthlink’s file. or in the Hepatitis Education Canada mini-video, What is a hepatitis C genotype?

Liver Cirrhosis
A condition that occurs when non-functioning scar tissue, tissue not healthy enough to help the liver work, replaces large amounts of normal functioning liver tissue. The scar tissue can be caused by lengthy injury or illness, such as chronic alcohol abuse or hep C. Symptoms, when they occur, include poor appetite, weight loss, fatigue, and just plain feeling sick. One is said to be cirrhotic when they have liver cirrhosis.

Liver Damage: In about a month, the liver can heal from small amounts of damage, such as the damage caused by a Tylenol overdose. More and more studies are also finding that the liver can repair itself after damage has been done.

Liver Fibrosis
A Liver fibrosis is the early stage of liver scarring. It happens when a liver tries to heal itself and in the process creates scar tissue that can’t do the work of normal liver cells. Fibrosis doesn’t cause symptoms but can lead to portal hypertension or liver cirrhosis. A liver biopsy is used to diagnosis it. Fibrosis can be stopped and some of the changes reversed if the underlying condition is treated.

Liver Fibrosis Stages
There are five stages of liver fibrosis, stage 0 to stage 4. Stage 0 means a liver is normal and doesn’t have fibrosis. Stage 4 is liver cirrhosis. BC PharmaCare requires a patient to have liver fibrosis stage 2 or higher in order to qualify for hep C treatment coverage. At stage 2, one may not know that their liver is damaged and may not be experience symptoms such as yellow skin or eyes or abdominal pain.

Null or Partial Response/rs
There are two forms of virologic non-response that are important to distinguish from each other: null response and partial response. Null response is when treatment doesn’t suppress the virus. Partial response saw decreased of hep C at 12 weeks but undesirably high HCV RNA levels in the blood at week 24. Both types of patients went through unsuccessful hep C treatments.

This test tells if the virus is present in one’s body and confirms the diagnosis of hepatitis C. The PCR test will also tell how much virus (viral load) there is and may, depending on the type of PCR test ordered, tell the genotype (strain) of hep C a person has.

PharmaCare Limited Coverage Drugs
BC PharmaCare’s limited coverage drugs are treatments that require patients to meet criteria pre-defined by PharmaCare to get their costs covered. Actual coverage depends on rules of the patient’s PharmaCare plan, including any annual deductible requirement. The hep C treatments covered by PharmaCare are all Limited Coverage Drugs that require Special Authority.

PharmaCare Special Authority
PharmaCare Special Authority grants coverage of a drug, medical supply, or medical device that otherwise would not be covered or that would only be partially covered. Coverage is provided for patients with specific medical circumstances and the actual reimbursement depends on the patient’s PharmaCare plan rules, including any annual deductible requirements. To receive coverage, Special Authority approval must be in place before the patient purchases the prescription. Coverage cannot be provided retroactively. The hep C treatments covered by PharmaCare are all Limited Coverage Drugs that require PharmaCare Special Authority.

When treatment has been successful but over time the virus has come back.

SVR stands for Sustained Viral Response. There is a time period, right after hep C treatment has been completed, when the HCV RNA, or the hep C virus, isn’t detectable in one’s blood. If the virus remains consistently undetectable over time, the chances of it coming back, or relapsing, are extremely low (less than 1%). When this happens, a SVR is thought to have been achieved.

Achieving SVR is the goal of hep C treatments. It is considered to be an hep C infection “cure”, a successful treatment. When it is achieved, the hep C virus can’t be detected in the blood, can’t be spread, and the progression of liver damage may stop or may slow down.

Patients who have already unsuccessfully tried to cure their hep C with usually pegylated interferon or an older generation of hep C treatment.

Treatment-Naive Patients/Patients who have never tried treatment
Patients who have never tried to cure their hep C.

Viral Load
The amount of virus (hep C RNA) in a given volume of blood. Viral loads during treatment are not predictive of whether or not a sustained virological response (SVR) will be achieved.

Viral Load Test
A Viral Load Test looks at the amount of virus (hep C RNA) in a given volume of blood. IU/ml is that given volume of blood used in reporting the test results and means International Units per milliliter. If one takes Sovaldi or Harvoni, the test is often preformed within 6 months prior to the start of treatment, at the end of treatment, and 12 and/or 24 weeks after treatment.

If you have any other terms to suggest, please let the Hep C Treatment Information Project know and we will update this list!

Further Links and Resources