Zepatier (elbasvir and grazoprevir)

Zepatier (elbasvir-grazoprevir): An Information SheetZepatier (elbasvir and grazoprevir) – General Information (PDF)

Targeted Genotypes: 1 or 4

Approved by Health Canada and Covered by BC PharmaCare: Yes

Treatment Description: Zepatier is a pill taken once-daily that is made up of elbasvir and grazoprevir, two direct-acting antivirals. It is an all-oral, short-course, interferon-free hep C treatment that can be taken with or without ribavirin.

Usage Warning: Tell your doctor if you take any of the following medicines as they may interact with Zepatier:

  • Tracleer: for pulmonary arterial hypertension
  • Alertec: to help people who cannot stay awake
  • Ketoconazole: to treat fungal infections
  • Tacrolimus: to stop organ transplant rejection
  • Elvitegravir, cobicistat, emtricitabine and tenofovir disoproxil fumarate: a drug combination to treat HIV
  • Treatments for high cholesterol

Daily Dose: 1 pill +/- Ribavirin

Treatment Lengths:

Treatment Regimens for Patients with Genotype 1 Hep C who are:
# of Weeks
Treatment-naïve with no liver cirrhosis or with compensated liver cirrhosis 12
Treatment-experienced who had the virus come back (relapsed) without liver cirrhosis or with compensated cirrhosis 12
With hep C genotype 1b who has never tried treatment and doesn’t have liver cirrhosis 12
With hep C genotype 1a treatment-experienced (on-treatment virologic failures) with no cirrhosis or with compensated cirrhosis 16 with Ribavirin (RBV)
Treatment Regimens for Patients with Genotype 4 Hep C who are: # of Weeks
Treatment-naïve with no cirrhosis or with compensated cirrhosis OR treatment-experienced (prior relapsers) without liver cirrhosis or compensated cirrhosis 12
Treatment-experienced (on-treatment virologic failures) patients with no cirrhosis or with compensated cirrhosis 16 with Ribavirin (RBV)

SVR: 90% – 98%

Co-infected with HIV: Same dose and length of treatment required

Common Side Effects Reported in Clinical Trials:

  • Diarrhea
  • Headache
  • Nausea
  • Tiredness (fatigue)
  • Trouble sleeping

Additional Information:

BC’s PharmaCare Eligibility for Zepatier

Zepatier is a limited coverage drug. To qualify for treatment coverage a patient must have ALL of the following:

  • A prescription from a hepatologist, a gastroenterologist, an infectious disease specialist or other physician experienced with treating hepatitis C;
  • Lab-confirmed hepatitis C genotype 1 or 4;
  • Lab-confirmed hepatitis C test done within the previous 12 months;
  • NOT currently being treated with another hepatitis C direct-acting antiviral drug;

Talk to your healthcare provider for more information or to start the treatment process.

Merck Care Program

For those who are prescribed Zepatier or pegylated interferon and ribavirin (Pegasys) there is Merck Care Program. For more information, contact your doctor, nurse, or call the program at: 1-866-872-5773.