Ombitasvir / Paritaprevir / Ritonavir and Dasabuvir

sq_drugsAs there seems to be a lot happening around ombitasvir / paritaprevir / ritonavir and dasabuvir (known in Canada as Holkira Pak and Viekira Pak in the USA), with CADTH seeking patient group input reports and PHCN putting out a call for patient input and survey participants, the Hepatitis C Treatment Information Project has put together the following treatment summary:

OMBITASVIR / PARITAPREVIR / RITONAVIR & DASABUVIR (HOLKIRA PAK)
Maker: AbbVie

3 DAA Co-formulated Drugs for Genotype 1:

  • Ombitasvir / paritaprevir / ritonavir +
  • Dasabuvir +/-
  • Ribavirin (RBV)

Adult Daily Doses:  4 pills per day +/- ribavirin

  • Ombitasvir / paritaprevir / ritonavir: 2 pills in the morning
  • Dasabuvir: 1 pill in the morning and 1 pill in the evening
  • Ribavirin (RBV): 1 pill in the morning and 1 pill in the evening

Length of Treatment:

12 or 24 weeks

Summary of Phase III Clinical Trial Results:

Clinical Trial Patients Treatment Regimen SVR12*
PEARL-II(12 weeks) Genotype 1bTreatment-experienced AbbVie regimen + RBV 97%(85/88)
AbbVie regimen only 100%(91/91)
PEARL-III(12 weeks) Genotype 1bTreatment-naive AbbVie regimen + RBV 99%(209/210)
AbbVie regimen only 99%(207/209)
PEARL-IV(12 weeks) Genotype 1aTreatment-naive AbbVie regimen + RBV 97%(97/100)
AbbVie regimen only 90%(185/205)
TURQUOISE-II(12 & 24 weeks) Genotype 1Treatment-naive & treatment-experienced with

compensated cirrhosis

AbbVie regimen + RBV, 12 weeks 92% (191/208)
AbbVie regimen + RBV, 24 weeks 96%(165/172)
SAPPHIRE-I(12 weeks) Genotype 1Treatment-naive AbbVie regimen + RBV 96%(455/473)
SAPPHIRE-II(12 weeks) Genotype 1 treatment-experienced AbbVie regimen + RBV 96%(286/297)

*In clinical trials for hepatitis C virus (HCV) infection treatments, the goal is to cure/achieve SVR (sustained viral response)/reduce the virus so that it can’t be detected in the blood and liver disease from hep C is stopped. SVR12 or SVR24 means that the treatments can achieve this response after 12 or 24 weeks of therapy.

Side Effects:

During the clinical trials, some reported side effects including headaches, fatigue, itchy skin, nausea, insomnia, and/or diarrhea. Headaches and fatigue were reported similarly by those taking the AbbVie regimen without ribavirin (RBV) and those taking it with ribavirin (RBV).

PHCN’s Ombitasvir / Paritaprevir / Ritonavir and Dasabuvir Survey

Please email hepctip@pacifichepc.org for more information about the survey or visit PHCN’s Hepatitis C Treatment Information Project for more information about ombitasvir / paritaprevir / ritonavir and dasabuvir and the different hep C treatments within the drug approval process.

Take this Survey

ombitasvir / paritaprevir / ritonavir and dasabuvir (HOLKIRA PAK) Survey Logo

Take this survey.

Survey participants with hep C or living with/caring for someone with hep C wholesale mlb jerseys needed immediately!

The LEDIPASVIR/SOFOSBUVIR Canadian Agency for Drugs and Technologies in Health (CADTH) is currently seeking patient group input reports for ombitasvir / paritaprevir Copyright / ritonavir and dasabuvir (HOLKIRA PAK), developed by AbbVie. Thus, Pacific Hepatitis C Network (PHCN) needs your help for our report.

The patient group input reports requested by CADTH are an important step towards getting new treatments for hep C more widely available in Canada and BC. You can be a part of this process!

The survey is newly la redesigned and includes 33 questions, mostly multiple choice, that are divided into five sections. cheap jerseys The sections that don’t needed pertain to you, such as the section about your experience with ombitasvir / paritaprevir / ritonavir and dasabuvir (HOLKIRA PAK) if you’ve never taken this hep C treatment, can be easily skipped. Those living with/caring for Managing someone with hep Simeprevir C are only asked to complete eight questions.

Survey responses are anonymous (we wholesale jerseys don’t for know your name or Истребитель other information about you). The information gathered will be used as part of a patient group input report for CADTH. By completing the survey you accept that PHCN can лиц use the information gathered by it in our patient group input report for CADTH.

Thank you for taking the time to voice your opinion and help advocate for a better tomorrow.

Please email hepctip@pacifichepc.org for more information about the survey or visit PHCN’s Hepatitis C Treatment Information Project for more information about ombitasvir / paritaprevir / ritonavir and dasabuvir (HOLKIRA PAK) and the different hep C treatments within the drug pipeline.

PharmaCare Approves Simeprevir PegIFN/RBV Combination

sq_checkJanssen Inc.’s simeprevir, brand name Galexos, in combination with peginterferon/ribavirin was V110 just approved by BC’s PharmaCare for the treatment of chronic hepatitis C genotype 1 in patients with or without Notice compensated cirrhosis and who have:

  • never tried to treat their wholesale nfl jerseys hepatitis C
    OR
  • tried treatment but the virus came back
    OR
  • tried treatment but weren’t cured

AND

Who Post have ALL of the following:

  • Lab-confirmed hepatitis C genotype 1
  • A prescription for the treatment from a qualified healthcare provider
  • Detectable levels of hep C in the last 6 months
  • Recent lab-confirmation of NS3 Q80K polymorphism negative for patients with hep C genotype 1a cheap jerseys subtype or genotype 1 with indeterminate subtype. Retesting is required is for all those who had their genotype tested before May 1, 2012.
  • A liver fibrosis stage F2 or greater

BUT

Who have NOT been or ARE NOT being cheap nfl jerseys treated with a LEDIPASVIR/SOFOSBUVIR protease inhibitor.

Please ask your wholesale jerseys healthcare provider for more information about simeprevir (Galexos) in combination with peginterferon/ribavirin (PegIFN/RBV) and about other hep C cheap mlb jerseys treatments.

For more Survey information about currently Bro approved hep C treatments in BC, emerging treatments, the drug approval process in Canada and BC, or hep C support programs, please visit PHCN’s Hepatitis C Treatment Information Project or email hepctip@pacifichepc.org.

Notice of Compliance for ledipasvir/sofosbuvir

sq_drugsGilead Sciences, Inc. announced yesterday that Health Canada has issued a Notice of Compliance for ledipasvir/sofosbuvir (Harvoni), the first ?irketleri once-daily single tablet regimen for the treatment of chronic hepatitis C genotype Dr.SiLnT 1 infection in adults. The technical tablet combines wholesale NFL jerseys the NS5A inhibitor ledipasvir with the Wholesale Miami Dolphins Jerseys nucleotide analog polymerase inhibitor sofosbuvir (Sovaldi) cheap NFL jerseys for a 8, 12, or 24 week treatment duration.

The press release programa that Gilead Sciences posted TAKERS! regarding this ledipasvir/sofosbuvir development also includes information about Gilead’s Momentum Support Program in wholesale jerseys Canada.

For more information about currently approved hep C treatments in BC, new and Winter, emerging drugs, ASAP! the drug approval process in Canada and BC, or hep C support programs, please visit PHCN’s Hepatitis C Treatment Information Project or email hepctip@pacifichepc.org.

THANK YOU LEDIPASVIR/SOFOSBUVIR SURVEY TAKERS!

sq_homePacific Hepatitis C Network (PHCN) would like to thank all of those who completed our ledipasvir/sofosbuvir (Harvoni) survey.

The survey was completed wholesale jerseys by dünya! more members than pastor expected and the opinions and experiences that were shared were not just invaluable while writing the patient group input report for the Canadian Agency for Drugs and Technologies in Health (CADTH), but will also be invaluable while creating future surveys.

Yes, there will be future surveys and future blog posts similar to the last post, requesting survey takers, and this post, thanking survey takers. Our task is not done! New hep C treatments are currently making their way through the wholesale jerseys China drug pipeline and we have to be a part of this process!

As we use your comments and suggestions to tweak the ledipasvir/sofosbuvir participants (Harvoni) survey for possible future use, we wait in great anticipation for the next time patient input is cheap jerseys requested by CADTH. Please join us in this anticipation and keep a look out for future requests for survey participants as new treatments are coming and CADTH will again need to hear about our experiences with hep C and our opinions about treatments.

For more information about currently approved hep C фундамент treatments in BC, new and emerging drugs, the drug approval process in Canada and BC, or resources to help wholesale mlb jerseys in getting ready for gegen treatment, please visit PHCN’s Hepatitis C Treatment Information Project or email hepctip@pacifichepc.org.

Survey participants needed ASAP!

Ledipasvir/Sofosbuvir (Harvoni) Survey LogoTwo cheap jerseys months cheap nba jerseys into cheap jerseys PHCN‘s Yet Treatment Information K?benhavns Project and the information embodying the resource has been changed and updated numerous times. One Friday afternoon, for example, was spent updating the project’s Drug Pipeline Diagram, only to realize that the new updates were already out of dated and that the work had to be redone.

With all of the changes taking place around treatment for hepatitis C, it’s an exciting time to be following the upcoming drugs through the drug approval process in Canada and BC.

During the past summer, for example, one of the drugs, Incivek, which had once emerged with promise in the fight against hepatitis C but required interferon, was discontinued by its maker, Vertex, as newer, improved therapies, not requiring interferon, advanced.

This announcement came on the heels of Vertex’s earlier announcement that it was ending its hep C research and development program.

But it’s not just an exciting time to watch and wait as the next generation of therapies advance through the drug pipeline, it’s also a great time to get involved, have your voice heard, and possibly help as decisions are made regarding newly emerging drugs!

On that note, PHCN requires survey participants with hep C or living with/caring for someone with hep C ASAP!

The survey’s link is: http://www.fluidsurveys.com/s/CADTH_Led_Sof_PHCN/

The survey includes 36, mostly multiple choice, questions that are divided into 5 sections. The sections that don’t pertain to you can be easily skipped. The survey’s 5 sections ask about:

  • The impact of hep C on your life (8 questions)
  • Your experience with current hep C treatments (9 questions)
  • The impact on caregivers (4 questions)
  • Your expectations and experience with Harvoni (ledipasvir/sofosbuvir) after taking the treatment (10 questions)
  • Your expectations of (Harvoni) ledipasvir/sofosbuvir (5 questions)

Survey responses are anonymous (we don’t know your name or other information about you). The information gathered will be used as part of a patient group input report about the above topics for the Canadian Agency for Drugs and Technologies in Health (CADTH). By completing the survey you accept that Pacific Hepatitis C Network (PHCN) can use the information gathered in the survey in our patient group input report for CADTH.

The patient group input reports requested by CADTH are an important step towards getting new treatments for hep C more widely available in Canada and BC. You can be a part of this process!

Please email hepctip@pacifichepc.org for more information.

Thank you for taking the time to voice your opinion and help advocate for a better tomorrow!