Treatments Covered by BC PharmaCare for Hep C Genotypes 2-6

Pan-Genotypic Hepatitis C Treatments: The BasicsPharmaCare Covered Treatments for Hep C Genotypes 2 – 6

Pegylated Interferon with Ribavirin (PR)* Ribavirin Sovaldi (sofosbuvir) with ribavirin**
Drug Class Nucleoside Analog Nucleotide NS5B Polymerase Inhibitor
Targeted Genotypes (GT) 2 – 6 2, 3 2, 3
Approximate SVR GT 2: < 80% See Sovadi (sofosbuvir) with ribavirin

The amount of daily pills required depends on one’s weight. Typically, the dose is 1,000 mg/day for persons less than 165 lbs. (75 kg.) and 1,200 mg/day for those 165 lbs. (75 kg.) or greater.

GT 2: 85 – 95%
GT 4: < 65%
GT 3, 5, 6: <40% GT 3: 75 – 85%
PR Required This is PR No
Daily Pills ribavirin + weekly pegylated interferon (PI) 1 + ribavirin
Weeks of Treatment
14 or 24 Genotype 2: 12
Genotype 3: 24
Possible Side Effects (Taking treatment with ribavirin can increase the type, frequency, and intensity of side effects)
  • Can’t Sleep
  • Depression / mood change
  • Diarrhea
  • Dizziness
  • Dry mouth
  • Fatigue / weakness
  • Fever
  • Flulike / Cold like symptoms
  • Hair loss
  • Headache
  • Low platelets (thrombocytopenia)
  • Low white cells (neutropenia)
  • Muscle / joint / back aches
  • Nausea
  • Stomach issues
  • Tiredness
  • Anemia, hemolytic (low red cells)
  • Dizziness / lightheadedness
  • Fatigue
  • Increased heart rate
  • Insomnia
  • Itchy / dry skin
  • Loss of appetite
  • Mood issues (anxiety, depression, irritability, moodiness)
  • Nausea
  • Shortness of breath
  • Taste changes
  • Trouble concentrating
  • Upset stomach (dyspepsia)
  • Weakness
  • Headache
  • Tiredness
Drug Interactions (Please see online product monographs for more information.) Do not take ribavirin if you are taking didanosine or zidovudine. Tell your doctor if you are taking azathioprine. Ribavirin is a drug that may harm fetuses. Tell your doctor if you may be or may become pregnant. Sovaldi can not be taken by those:

  • With bradycardia
  • Taking amiodarone

It may interact with drugs and herbs that are metabolized in the liver and intestines such as St. John’s wort.

BC’s PharmaCare Coverage Requirements Genotype 2: Treatment naive patients who can’t take interferon for medical reasons or have already tried PR
Genotype 3: Patients who have never tried treatment AND who can’t take interferon for medical reasons OR have already tried PR
  • Lab-confirmed hepatitis C and the right genotypes for the treatment
  • Detectable levels of hep C in the last 6 months
  • A liver fibrosis stage F2 or greater
  • A Special Authority request completed by a specialist or experienced physician
  • NOT currently treated with another hep C treatment/hep C antiviral agent
Special PharmaCare Notes In exceptional cases, requests that do not meet the criteria above may receive special consideration for coverage if the physician provides additional documentation of disease progression and/or for other patient-specific considerations. The Hepatitis Drug Benefit Adjudication Advisory Committee reviews exceptional case submissions.
Additional PharmaCare Notes Ribavirin and Sovadi (sofosbuvir) do not come together. Re-treatment requests will not be considered. PharmaCare covered for HIV/HCV coinfection if above criteria is met
Patient Assistance Program Contact Information PEGAssist Patient Support Program 1-877-734-2797 Ibavyr Patient Support Program 1-844-602-6858 Gilead’s Momentum Patient Assistance Program 1-855-447-7977
*PR stands for pegylated interferon with ribavirin. It may be combined with other drugs for the treatment of hep C genotype 1 or it may be prescribed alone for hep C genotypes 2 – 6.**Sovaldi (sofosbuvir) and pegylated interferon with ribavirin is approved for use in Canada to treat hep C genotype 4 but isn’t covered by BC’s PharmaCare.

Further Treatment Links and Resources about Treatment for Hep C Genotypes 2-6

Treatment Coverage Across Canada
Treatment coverage across Canada is decided upon by each province and territory. This means that not only can treatments vary, and be compared to each other, but treatment coverage may vary from location to location as well. This page is a quick summary of what hepatitis C treatments are covered, in some form or another, by the different provinces and territories across Canada. (Canadian)

Hepatitis C Treatment OPTIONS: Basic Information for Patients by Hepatitis Education Canada
This interactive tool will provide you with personal hepatitis C treatment recommendations that can be printed for reference or to taken your provider. (Canadian)

PharmaCare Covered Treatments for Hep C Genotypes 2 - 6